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No Access Submitted: 14 August 2019 Accepted: 11 October 2019 Published Online: 12 November 2019

  • Ultrafast ultrasound imaging in acoustic microbubble trapping
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Appl. Phys. Lett. 115, 203701 (2019); https://doi.org/10.1063/1.5124437
Hanmin Peng1,2,a), Xuejun Qian1,3,a), Linli Mao2, Laiming Jiang3, Yizhe Sun1, and Qifa Zhou1,3,b)
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ABSTRACT
The lack of actively targeted nanocarriers and a low drug concentration in lesions are two of the main problems in targeted therapy for clinical use. In this paper, an ultrasound-induced trapping and ultrafast imaging system for flowing microbubbles is proposed to increase the effective drug dose and achieve real-time positioning. A finite element method model is established to analyze microbubble tracing in a fluid flow model at 2.5 MHz, which demonstrates how the interaction of acoustic radiation force (ARF) and flowing drag force is able to trap microbubbles and move them to a specific location. This motion can be explicitly imaged and captured by ultrafast plane wave imaging with a 1D array ultrasound probe at 18 MHz. The use of this plane wave and ARF technique can be beneficial for fast localization, monitoring, and manipulation of drug delivery bubbles for targeted release at 10 mm depth in a noninvasive and feasible way. Therefore, this ultrasound technology can be a useful tool to increase the local drug concentration in an accurate location for clinical use.
This work was supported by the following funding organizations in China: the National Natural Science Foundation of China (Grant No. 51875280), the outstanding Youth Science Foundation of Jiangsu province (Grant No. BK20180067), and the China Scholarship Council (Grant No. 201806835027). Thanks to Robert Wodnicki for proofreading the article.

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  1. © 2019 Author(s). Published under license by AIP Publishing.

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